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Hashimoto’s diet: the Sirtfood diet helped Adele lose 40kgs — BOOST Thyroid: Hashimoto’s and Hypothyroid App

Hashimoto’s diet: the Sirtfood diet helped Adele lose 40kgs — BOOST Thyroid: Hashimoto’s and Hypothyroid App

  • October 28, 2020
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For original article click here

Skinny Adele singing in 2019

Skinny Adele singing in 2019

The ins and outs of diet that helped Adele lose 40kgs

The basis of the Sirtfood diet is to activate molecules called sirtuins, which are naturally present in your body.

Activated sirtuins can help slow down aging while helping with regulating weight (1).

What are sirtuins?

Sirtuins (aka silent information regulator 2 family) are molecules necessary for metabolism. They also protect your body from stress.

When on a calorie restriction diet, sirtuins help prolong your lifespan. They’re activated when energy in the body is low—through stress or calorie restriction.

At this point only the most basic cellular functions are still running, which helps cells live longer (2, 3). Sirtuin works by interacting with insulin and molecules activated by insulin (1, 5-7).

Sirtuins also help reduce white fat mass and through that they slow down how your body ages (8).

Sirtuin activating compounds (STACs)

There are a number of foods that can activate sirtuins in your body, although the adequate concentration needed to activate sirtuins in humans is still unknown (1).

These natural molecules are considered to be sirtuin activators:

  • Resveratrol
    Found in raspberries, blueberries, peanuts, and red grape skins—helps fight inflammation and improve heart health (9)

  • Piceatannol
    Found in red wine and white tea—it’s used as herbal medicine in Asia (10)

  • Fisetin
    Found in strawberries—can help enhancing long-term memory (11)

  • Quercetin
    Found in capers, apples, tea, onion, kale, citrus fruit, and berries—helps fight inflammation (12)

  • Polyphenols
    Found in curcumin and turmeric—effect depends on concentrations (in low doses it’s beneficial, in high doses it might be harmful (13, 14)

  • Melatonin (15)

  • Oligonol
    Found mostly in lychees—contains anti-inflammatory properties (16)

  • Omega-3 
    Found in flaxseed and fish—some research suggests it might be helpful in boosting sirtuin levels in the blood (17)

These natural compounds can help improve insulin sensitivity and lower blood sugar levels (18).

Exercise is also beneficial for sirtuin activation. Long-term moderate exercise has been shown to increase sirtuin levels in muscles (19).

Sirtuin blockers

Nicotinamide is a form of vitamin B3. It’s found in a lot of food including meat, poultry, tuna, salmon, cereals, legumes, and seeds. and it’s used as a dietary supplement.

Although nicotinamide is beneficial for brain functioning and metabolism, it can block the activity of some sirtuins (20).

Sirtuins and thyroid health

Sirtuins are involved in thyroid activity. They help enhance the activation of the T3 hormone in the liver (21).

Sirtuins can also help to reduce the risk of developing an autoimmune disease. They can also help with managing flare-ups (22).

If you’re trying the  Sirtfood diet, use BOOST Thyroid to track your diet and your weight to establish how helpful this diet is for you.

If you’d like to receive Sirtfood diet recipes, join BOOST Thyroid Membership.


Photo: Egghead06. Design: BOOST Thyroid.


  1. Wenzel U. Nutrition, sirtuins and aging, 2006

  2. Johnson TE, et al. Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease, 2002

  3. Tissenbaum HA, et al. Increased dosage of a sir-2 gene extends life span in Caenorhabditis elegans, 2001

  4. Anderson RM, et al. Yeast life-span extension by calorie restriction is independent of NAD fluctuation, 2003

  5. Merry B.J. Oxidative stress and mitochondrial function with aging—the effects of calorie restriction, 2004

  6. Barbieri M, et al. Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans, 2003

  7. Brunet A, et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase, 2004

  8. Picard F, et al. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma, 2004

  9. Howitz KT, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan, 2003

  10. Gerhart-Hines Z, et al. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha, 2007

  11. Maher P, et al. Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory, 2006

  12. Shaik YB, et al. Role of quercetin (a natural herbal compound) in allergy and inflammation, 2006

  13. Chung S, et al. Regulation of SIRT1 in cellular functions: role of polyphenols, 2010

  14. Calabrese EJ. Hormesis: from mainstream to therapy, 2014

  15. Ramis MR, et al. Caloric restriction, resveratrol and melatonin: role of SIRT1 and implications for aging and related-diseases, 2015

  16. Park S, et al. Oligonol promotes anti-aging pathways via modulation of SIRT1-AMPK-autophagy pathway, 2016

  17. Wu A, . Omega-3 fatty acids supplementation restores mechanisms that maintain brain homeostasis in traumatic brain injury, 2007

  18. Milne JC, et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes, 2007

  19. Bori Z, et al. The effects of aging, physical training, and a single bout of exercise on mitochondrial protein expression in human skeletal muscle, 2012

  20. Schmidt MT, et al. Coenzyme specificity of Sir2 protein deacetylases: implications for physiological regulation, 2004

  21. Thakran S, et al. Role of sirtuin 1 in the regulation of hepatic gene expression by thyroid hormone, 2013

  22. Kong S, et al. Sirtuin 1 in immune regulation and autoimmunity, 2012

Clar McWeeneyJanuary 24, 2020

For original article click here

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